View source for 4jnm


==Discovery of Potent and Efficacious Urea-containing Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors with Reduced CYP2C9 Inhibition Properties==
<StructureSection load='4jnm' size='340' side='right'caption='[[4jnm]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4jnm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JNM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JNM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1LJ:1-[(6-AMINOPYRIDIN-3-YL)METHYL]-3-[4-(PHENYLSULFONYL)PHENYL]UREA'>1LJ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jnm OCA], [https://pdbe.org/4jnm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jnm RCSB], [https://www.ebi.ac.uk/pdbsum/4jnm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jnm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).

==See Also==
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bair KW]]
[[Category: Bauer P]]
[[Category: Baumeister T]]
[[Category: Buckmelter AJ]]
[[Category: Caligiuri M]]
[[Category: Clodfelter KH]]
[[Category: Dragovich PS]]
[[Category: Fu B]]
[[Category: Gunzner-Toste J]]
[[Category: Han B]]
[[Category: Ho Y]]
[[Category: Kley N]]
[[Category: Liederer B]]
[[Category: Lin J]]
[[Category: Mukadam S]]
[[Category: O'Brien T]]
[[Category: Oh A]]
[[Category: Reynolds DJ]]
[[Category: Sharma G]]
[[Category: Skelton N]]
[[Category: Smith CC]]
[[Category: Wang W]]
[[Category: Wang Z]]
[[Category: Xiao Y]]
[[Category: Yuen P]]
[[Category: Zak M]]
[[Category: Zhang L]]
[[Category: Zhao G]]
[[Category: Zheng X]]