View source for 4jh7


==Crystal Structure of FosB from Bacillus cereus with Manganese and L-Cysteine-Fosfomycin Product==
<StructureSection load='4jh7' size='340' side='right'caption='[[4jh7]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4jh7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_cereus_ATCC_10987 Bacillus cereus ATCC 10987]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JH7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JH7 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1KM:(2R)-2-AZANYL-3-[(1R,2S)-2-OXIDANYL-1-PHOSPHONO-PROPYL]SULFANYL-PROPANOIC+ACID'>1KM</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jh7 OCA], [https://pdbe.org/4jh7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jh7 RCSB], [https://www.ebi.ac.uk/pdbsum/4jh7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jh7 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FOSB_BACC1 FOSB_BACC1] Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity).

==See Also==
*[[Metallothiol transferase FosB|Metallothiol transferase FosB]]
__TOC__
</StructureSection>
[[Category: Bacillus cereus ATCC 10987]]
[[Category: Large Structures]]
[[Category: Armstrong RN]]
[[Category: Cook PD]]
[[Category: Harp J]]
[[Category: Jagessar K]]
[[Category: Keithly ME]]
[[Category: Thompson MK]]