View source for 4htm


==Mechanism of CREB Recognition and Coactivation by the CREB Regulated Transcriptional Coactivator CRTC2==
<StructureSection load='4htm' size='340' side='right'caption='[[4htm]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4htm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HTM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HTM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4htm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4htm OCA], [https://pdbe.org/4htm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4htm RCSB], [https://www.ebi.ac.uk/pdbsum/4htm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4htm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CRTC2_HUMAN CRTC2_HUMAN] Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).<ref>PMID:14506290</ref> <ref>PMID:14536081</ref> <ref>PMID:15454081</ref> <ref>PMID:16809310</ref> <ref>PMID:16817901</ref> <ref>PMID:16980408</ref> <ref>PMID:17210223</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Kumar GS]]
[[Category: Luo Q]]
[[Category: Mayo K]]
[[Category: Montminy M]]
[[Category: Radhakrishnan I]]
[[Category: Talai A]]
[[Category: Tsai W-W]]
[[Category: Urday-Zaa JC]]
[[Category: Viste K]]