View source for 4ezv


==Crystal structure of the substrate binding domain of E.coli DnaK in complex with PR-bombesin in space group P21212==
<StructureSection load='4ezv' size='340' side='right'caption='[[4ezv]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ezv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bombina_maxima Bombina maxima] and [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EZV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ezv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ezv OCA], [https://pdbe.org/4ezv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ezv RCSB], [https://www.ebi.ac.uk/pdbsum/4ezv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ezv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DNAK_ECOLI DNAK_ECOLI] Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332]

==See Also==
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
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</StructureSection>
[[Category: Bombina maxima]]
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Straeter N]]
[[Category: Zahn M]]