View source for 4er6


==Crystal structure of human DOT1L in complex with inhibitor SGC0946==
<StructureSection load='4er6' size='340' side='right'caption='[[4er6]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4er6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ER6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AW2:5-BROMO-7-{5-[(3-{[(4-TERT-BUTYLPHENYL)CARBAMOYL]AMINO}PROPYL)(PROPAN-2-YL)AMINO]-5-DEOXY-BETA-D-RIBOFURANOSYL}-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE'>AW2</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4er6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4er6 OCA], [https://pdbe.org/4er6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4er6 RCSB], [https://www.ebi.ac.uk/pdbsum/4er6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4er6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.

==See Also==
*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Bradner JE]]
[[Category: Brown PJ]]
[[Category: Edwards AM]]
[[Category: Li Y]]
[[Category: Nguyen KT]]
[[Category: Schapira M]]
[[Category: Scopton A]]
[[Category: Tempel W]]
[[Category: Vedadi M]]
[[Category: Wernimont AK]]
[[Category: Yu W]]