View source for 4d0l


==Phosphatidylinositol 4-kinase III beta-PIK93 in a complex with Rab11a- GTP gammaS==
<StructureSection load='4d0l' size='340' side='right'caption='[[4d0l]], [[Resolution|resolution]] 2.94&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4d0l]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D0L FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.94&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=093:N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)-+PHENYLTHIAZOLE-2-YL)-ACETAMIDE'>093</scene>, <scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d0l OCA], [https://pdbe.org/4d0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d0l RCSB], [https://www.ebi.ac.uk/pdbsum/4d0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d0l ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PI4KB_HUMAN PI4KB_HUMAN] Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity).<ref>PMID:9405935</ref> <ref>PMID:10559940</ref> <ref>PMID:12749687</ref> 
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== Publication Abstract from PubMed ==
Phosphatidylinositol 4-kinases (PI4Ks) and small guanosine triphosphatases (GTPases) are essential for processes that require expansion and remodeling of phosphatidylinositol 4-phosphate (PI4P)-containing membranes, including cytokinesis, intracellular development of malarial pathogens, and replication of a wide range of RNA viruses. However, the structural basis for coordination of PI4K, GTPases, and their effectors is unknown. Here, we describe structures of PI4Kbeta (PI4KIIIbeta) bound to the small GTPase Rab11a without and with the Rab11 effector protein FIP3. The Rab11-PI4KIIIbeta interface is distinct compared with known structures of Rab complexes and does not involve switch regions used by GTPase effectors. Our data provide a mechanism for how PI4KIIIbeta coordinates Rab11 and its effectors on PI4P-enriched membranes and also provide strategies for the design of specific inhibitors that could potentially target plasmodial PI4KIIIbeta to combat malaria.

Structures of PI4KIIIbeta complexes show simultaneous recruitment of Rab11 and its effectors.,Burke JE, Inglis AJ, Perisic O, Masson GR, McLaughlin SH, Rutaganira F, Shokat KM, Williams RL Science. 2014 May 30;344(6187):1035-8. doi: 10.1126/science.1253397. PMID:24876499<ref>PMID:24876499</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4d0l" style="background-color:#fffaf0;"></div>

==See Also==
*[[Phosphatidylinositol 4-kinase|Phosphatidylinositol 4-kinase]]
*[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Burke JE]]
[[Category: Inglis AJ]]
[[Category: Masson GR]]
[[Category: McLaughin SH]]
[[Category: Perisic O]]
[[Category: Rutaganira F]]
[[Category: Shokat KM]]
[[Category: Williams RL]]