View source for 4cva


==MPS1 kinase with 3-aminopyridin-2-one inhibitors==
<StructureSection load='4cva' size='340' side='right'caption='[[4cva]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4cva]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CVA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>, <scene name='pdbligand=WBI:N-(6-OXO-1,6-DIHYDRO-3,4-BIPYRIDIN-5-YL)-4-(PIPERIDIN-1-YL)BENZAMIDE'>WBI</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cva OCA], [https://pdbe.org/4cva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cva RCSB], [https://www.ebi.ac.uk/pdbsum/4cva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cva ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref> 

==See Also==
*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bavetsias V]]
[[Category: Bayliss R]]
[[Category: Fearon D]]
[[Category: Jones K]]
[[Category: Schmitt J]]
[[Category: Westwood IM]]
[[Category: VanMontfort RLM]]