View source for 3zpc


==Acinetobacter baumannii RibD, form 1==
<StructureSection load='3zpc' size='340' side='right'caption='[[3zpc]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3zpc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZPC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZPC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zpc OCA], [https://pdbe.org/3zpc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zpc RCSB], [https://www.ebi.ac.uk/pdbsum/3zpc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zpc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/D0CB74_ACIB2 D0CB74_ACIB2] Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.[ARBA:ARBA00002151][PIRNR:PIRNR006769]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase (RibD) represents a potential antibacterial drug target. The structure of recombinant Acinetobacter baumannii RibD is reported in orthorhombic and tetragonal crystal forms at 2.2 and 2.0 A resolution, respectively. Comparisons with orthologous structures in the Protein Data Bank indicated close similarities. The tetragonal crystal form was obtained in the presence of guanosine monophosphate, which surprisingly was observed to occupy the adenine-binding site of the reductase domain.

Structure of diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase from Acinetobacter baumannii.,Dawson A, Trumper P, Chrysostomou G, Hunter WN Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jun;69(Pt 6):611-7. doi:, 10.1107/S174430911301292X. Epub 2013 May 23. PMID:23722836<ref>PMID:23722836</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3zpc" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Acinetobacter baumannii]]
[[Category: Large Structures]]
[[Category: Chrysostomou G]]
[[Category: Dawson A]]
[[Category: Hunter WN]]
[[Category: Trumper P]]