View source for 3uv7


==Ec_IspH in complex with buta-2,3-dienyl diphosphate (1300)==
<StructureSection load='3uv7' size='340' side='right'caption='[[3uv7]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3uv7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UV7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UV7 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0CN:BUTA-2,3-DIEN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>0CN</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uv7 OCA], [https://pdbe.org/3uv7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uv7 RCSB], [https://www.ebi.ac.uk/pdbsum/3uv7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uv7 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ISPH_ECOLI ISPH_ECOLI] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth.<ref>PMID:19569147</ref> <ref>PMID:20080550</ref> <ref>PMID:22137895</ref> 

==See Also==
*[[4-hydroxy-3-methylbut-2-enyl diphosphate reductase 3D structures|4-hydroxy-3-methylbut-2-enyl diphosphate reductase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Bacher A]]
[[Category: Eisenreich W]]
[[Category: Groll M]]
[[Category: Oldfield E]]
[[Category: Schulz C]]
[[Category: Span I]]
[[Category: Wang K]]
[[Category: Wang W]]
[[Category: Zhang Y]]