View source for 3sal


==Crystal Structure of Influenza A Virus Neuraminidase N5==
<StructureSection load='3sal' size='340' side='right'caption='[[3sal]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3sal]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/duck/Alberta/60/1976(H12N5)) Influenza A virus (A/duck/Alberta/60/1976(H12N5))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SAL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SAL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sal FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sal OCA], [https://pdbe.org/3sal PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sal RCSB], [https://www.ebi.ac.uk/pdbsum/3sal PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sal ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A1ILL9_I76A2 A1ILL9_I76A2] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
There are 9 serotypes of neuraminidase (NA) from influenza A virus (N1 to N9), which are classified into two groups based on primary sequences (groups 1 and 2). The structural hallmark of the two groups is the presence or absence of an extra 150-cavity (formed by the 150-loop) in the active site. Thus far, structures of NAs from 6 out of the 9 serotypes have been solved. Here, we solved the N5 structure, the last unknown structure group 1 serotype with a unique Asn147 residue in its 150-loop, demonstrating that it has an extended 150-cavity that closes upon inhibitor binding.

Influenza a virus n5 neuraminidase has an extended 150-cavity.,Wang M, Qi J, Liu Y, Vavricka CJ, Wu Y, Li Q, Gao GF J Virol. 2011 Aug;85(16):8431-5. Epub 2011 Jun 8. PMID:21653672<ref>PMID:21653672</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3sal" style="background-color:#fffaf0;"></div>

==See Also==
*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Gao GF]]
[[Category: Li Q]]
[[Category: Liu Y]]
[[Category: Qi JX]]
[[Category: Vavricka CJ]]
[[Category: Wang MY]]
[[Category: Wu Y]]