View source for 3s24


==Crystal structure of human mRNA guanylyltransferase==
<StructureSection load='3s24' size='340' side='right'caption='[[3s24]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3s24]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S24 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S24 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.0137&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s24 OCA], [https://pdbe.org/3s24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s24 RCSB], [https://www.ebi.ac.uk/pdbsum/3s24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s24 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MCE1_HUMAN MCE1_HUMAN] Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arnold E]]
[[Category: Bauman JD]]
[[Category: Chu C]]
[[Category: Das K]]
[[Category: Guan R]]
[[Category: Montelione GT]]
[[Category: Qiu W]]
[[Category: Shatkin AJ]]
[[Category: Thyminski JR]]