View source for 3rnj


==Crystal structure of the SH3 domain from IRSp53 (BAIAP2)==
<StructureSection load='3rnj' size='340' side='right'caption='[[3rnj]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3rnj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RNJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RNJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EDT:{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC+ACID'>EDT</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rnj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rnj OCA], [https://pdbe.org/3rnj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rnj RCSB], [https://www.ebi.ac.uk/pdbsum/3rnj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rnj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BAIP2_HUMAN BAIP2_HUMAN] Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.<ref>PMID:11130076</ref> <ref>PMID:11696321</ref> <ref>PMID:14752106</ref> <ref>PMID:19366662</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Barilari M]]
[[Category: Bountra C]]
[[Category: Chaikuad A]]
[[Category: Dente L]]
[[Category: Edwards AM]]
[[Category: Feller SM]]
[[Category: Filippakopoulos P]]
[[Category: Knapp S]]
[[Category: Muniz JRC]]
[[Category: Raynor J]]
[[Category: Simister PC]]
[[Category: Tregubova A]]
[[Category: Vollmar M]]
[[Category: Weigelt J]]
[[Category: Von Delft F]]