View source for 3qa8


==Crystal Structure of inhibitor of kappa B kinase beta==
<StructureSection load='3qa8' size='340' side='right'caption='[[3qa8]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3qa8]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QA8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QA8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qa8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qa8 OCA], [https://pdbe.org/3qa8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qa8 RCSB], [https://www.ebi.ac.uk/pdbsum/3qa8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qa8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q6INT1_XENLA Q6INT1_XENLA] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Inhibitor of kappaB (IkappaB) kinase (IKK) phosphorylates IkappaB proteins, leading to their degradation and the liberation of nuclear factor kappaB for gene transcription. Here we report the crystal structure of IKKbeta in complex with an inhibitor, at a resolution of 3.6 A. The structure reveals a trimodular architecture comprising the kinase domain, a ubiquitin-like domain (ULD) and an elongated, alpha-helical scaffold/dimerization domain (SDD). Unexpectedly, the predicted leucine zipper and helix-loop-helix motifs do not form these structures but are part of the SDD. The ULD and SDD mediate a critical interaction with IkappaBalpha that restricts substrate specificity, and the ULD is also required for catalytic activity. The SDD mediates IKKbeta dimerization, but dimerization per se is not important for maintaining IKKbeta activity and instead is required for IKKbeta activation. Other IKK family members, IKKalpha, TBK1 and IKK-i, may have a similar trimodular architecture and function.

Crystal structure of inhibitor of kappaB kinase beta,Xu G, Lo YC, Li Q, Napolitano G, Wu X, Jiang X, Dreano M, Karin M, Wu H Nature. 2011 Mar 20. PMID:21423167<ref>PMID:21423167</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3qa8" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Xenopus laevis]]
[[Category: Dreano M]]
[[Category: Jiang X]]
[[Category: Karin M]]
[[Category: Li Q]]
[[Category: Lo YC]]
[[Category: Napolitano G]]
[[Category: Wu H]]
[[Category: Wu X]]
[[Category: Xu G]]