View source for 3pov


==Crystal structure of a SOX-DNA complex==
<StructureSection load='3pov' size='340' side='right'caption='[[3pov]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3pov]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_herpesvirus_8_type_M Human herpesvirus 8 type M]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3POV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3POV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pov OCA], [https://pdbe.org/3pov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pov RCSB], [https://www.ebi.ac.uk/pdbsum/3pov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pov ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/P88925_HHV8 P88925_HHV8] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The early lytic phase of Kaposi's sarcoma herpesvirus infection is characterized by viral replication and the global degradation (shutoff) of host mRNA. Key to both activities is the virally encoded alkaline exonuclease KSHV SOX. While the DNase activity of KSHV SOX is required for the resolution of viral genomic DNA as a precursor to encapsidation, its exact involvement in host shutoff remains to be determined. We present the first crystal structure of a KSHV SOX-DNA complex that has illuminated the catalytic mechanism underpinning both its endo and exonuclease activities. We further illustrate that KSHV SOX, similar to its Epstein-Barr virus homologue, has an intrinsic RNase activity in vitro that although an element of host shutoff, cannot solely account for the phenomenon.

Crystal structure of a KSHV-SOX-DNA complex: insights into the molecular mechanisms underlying DNase activity and host shutoff.,Bagneris C, Briggs LC, Savva R, Ebrahimi B, Barrett TE Nucleic Acids Res. 2011 Jul;39(13):5744-56. Epub 2011 Mar 17. PMID:21421561<ref>PMID:21421561</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3pov" style="background-color:#fffaf0;"></div>

==See Also==
*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human herpesvirus 8 type M]]
[[Category: Large Structures]]
[[Category: Bagneris C]]
[[Category: Barrett TE]]