View source for 3pel


==Structure of Greyhound Hemoglobin: Origin of High Oxygen Affinity==
<StructureSection load='3pel' size='340' side='right'caption='[[3pel]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3pel]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3n48 3n48]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PEL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pel OCA], [https://pdbe.org/3pel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pel RCSB], [https://www.ebi.ac.uk/pdbsum/3pel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pel ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HBA_CANLF HBA_CANLF] Involved in oxygen transport from the lung to the various peripheral tissues.  Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1. Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.[UniProtKB:P01946]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
This study presents the crystal structure of Greyhound hemoglobin (GrHb) determined to 1.9 A resolution. GrHb was found to crystallize with an alpha(1)beta(1) dimer in the asymmetric unit and belongs to the R2 state. Oxygen-affinity measurements combined with the fact that GrHb crystallizes in the R2 state despite the high-salt conditions used for crystallization strongly indicate that GrHb can serve as a model high-oxygen-affinity hemoglobin (Hb) for higher mammals, especially humans. Structural analysis of GrHb and its comparison with the R2-state of human Hb revealed several regions that can potentially contribute to the high oxygen affinity of GrHb and serve to rationalize the additional stability of the R2-state of GrHb. A previously well studied hydrophobic cluster of bar-headed goose Hb near alpha119 was also incorporated in the comparison between GrHb and human Hb. Finally, a structural comparison with generic dog Hb and maned wolf Hb was conducted, revealing that in contrast to GrHb these structures belong to the R state of Hb and raising the intriguing possibility of an additional allosteric factor co-purifying with GrHb that can modulate its quaternary structure.

Structure of Greyhound hemoglobin: origin of high oxygen affinity.,Bhatt VS, Zaldivar-Lopez S, Harris DR, Couto CG, Wang PG, Palmer AF Acta Crystallogr D Biol Crystallogr. 2011 May;67(Pt 5):395-402. Epub 2011, Apr 13. PMID:21543841<ref>PMID:21543841</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3pel" style="background-color:#fffaf0;"></div>

==See Also==
*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Canis lupus familiaris]]
[[Category: Large Structures]]
[[Category: Bhatt VS]]
[[Category: Couto CG]]
[[Category: Harris DR]]
[[Category: Palmer AF]]
[[Category: Wang PG]]
[[Category: Zaldivar-Lopez S]]