View source for 3j2j


==Empty coxsackievirus A9 capsid==
<SX load='3j2j' size='340' side='right' viewer='molstar' caption='[[3j2j]], [[Resolution|resolution]] 9.54&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3j2j]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Coxsackievirus_A9 Coxsackievirus A9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J2J FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 9.54&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j2j OCA], [https://pdbe.org/3j2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j2j RCSB], [https://www.ebi.ac.uk/pdbsum/3j2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j2j ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/POLG_CXA9 POLG_CXA9] Capsid proteins VP1, VP2, VP3 and VP4 form a closed capsid enclosing the viral positive strand RNA genome. VP4 lies on the inner surface of the protein shell formed by VP1, VP2 and VP3. All the three latter proteins contain a beta-sheet structure called beta-barrel jelly roll. Together they form an icosahedral capsid (T=3) composed of 60 copies of each VP1, VP2, and VP3, with a diameter of approximately 300 Angstroms. VP1 is situated at the 12 fivefold axes, whereas VP2 and VP3 are located at the quasi-sixfold axes (By similarity). Capsid proteins interact with host alpha-V/beta-6 integrin heterodimer to provide virion attachment target cell.  VP0 precursor is a component of immature procapsids (By similarity).  Protein 2A is a cysteine protease that is responsible for the cleavage between the P1 and P2 regions. It cleaves the host translation initiation factor EIF4G1, in order to shut down the capped cellular mRNA transcription (By similarity).  Protein 2B affects membrane integrity and cause an increase in membrane permeability (By similarity).  Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).  Protein 3A, via its hydrophobic domain, serves as membrane anchor. It also inhibits endoplasmic reticulum-to-Golgi transport (By similarity).  Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).  RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).

==See Also==
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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[[Category: Coxsackievirus A9]]
[[Category: Large Structures]]
[[Category: Butcher SJ]]
[[Category: Hyypia T]]
[[Category: Kajander T]]
[[Category: Laurinmaki P]]
[[Category: Seitsonen JJT]]
[[Category: Shakeel S]]
[[Category: Susi P]]