View source for 3ao5


==Fragment-based approach to the design of ligands targeting a novel site on HIV-1 integrase==
<StructureSection load='3ao5' size='340' side='right'caption='[[3ao5]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3ao5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AO5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AO5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BBY:5-(7-BROMO-1,3-BENZODIOXOL-5-YL)-1-METHYL-1H-PYRAZOL-3-AMINE'>BBY</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FRU:FRUCTOSE'>FRU</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900003:sucrose'>PRD_900003</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ao5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ao5 OCA], [https://pdbe.org/3ao5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ao5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ao5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ao5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q72498_9HIV1 Q72498_9HIV1] 

==See Also==
*[[Retroviral integrase 3D structures|Retroviral integrase 3D structures]]
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</StructureSection>
[[Category: Human immunodeficiency virus 1]]
[[Category: Large Structures]]
[[Category: Chalmers DK]]
[[Category: Headey SJ]]
[[Category: Parker MW]]
[[Category: Scanlon MJ]]
[[Category: Wielens J]]