View source for 2wa0


==Crystal structure of the human MAGEA4==
<StructureSection load='2wa0' size='340' side='right'caption='[[2wa0]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2wa0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WA0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WA0 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wa0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wa0 OCA], [https://pdbe.org/2wa0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wa0 RCSB], [https://www.ebi.ac.uk/pdbsum/2wa0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wa0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MAGA4_HUMAN MAGA4_HUMAN] Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wa/2wa0_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wa0 ConSurf].
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== Publication Abstract from PubMed ==
The MAGE (melanoma associated antigen) protein family are tumour-associated proteins normally present only in reproductive tissues such as germ cells of the testis. The human genome encodes over 60 MAGE genes of which one class (containing MAGE-A3 and MAGE-A4) are exclusively expressed in tumours, making them an attractive target for the development of targeted and immunotherapeutic cancer treatments. Some MAGE proteins are thought to play an active role in driving cancer, modulating the activity of E3 ubiquitin ligases on targets related to apoptosis. Here we determined the crystal structures of MAGE-A3 and MAGE-A4. Both proteins crystallized with a terminal peptide bound in a deep cleft between two tandem-arranged winged helix domains. MAGE-A3 (but not MAGE-A4), is predominantly dimeric in solution. Comparison of MAGE-A3 and MAGE-A3 with a structure of an effector-bound MAGE-G1 suggests that a major conformational rearrangement is required for binding, and that this conformational plasticity may be targeted by allosteric binders.

Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding.,Newman JA, Cooper CD, Roos AK, Aitkenhead H, Oppermann UC, Cho HJ, Osman R, Gileadi O PLoS One. 2016 Feb 24;11(2):e0148762. doi: 10.1371/journal.pone.0148762., eCollection 2016. PMID:26910052<ref>PMID:26910052</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2wa0" style="background-color:#fffaf0;"></div>

==See Also==
*[[Melanoma-associated antigen|Melanoma-associated antigen]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Berridge G]]
[[Category: Bountra C]]
[[Category: Bray J]]
[[Category: Burgess-Brown N]]
[[Category: Chaikuad A]]
[[Category: Cooper CDO]]
[[Category: Edwards A]]
[[Category: Elkins JM]]
[[Category: Filippakopoulos P]]
[[Category: Gileadi O]]
[[Category: Muniz J]]
[[Category: Oppermann U]]
[[Category: Pike ACW]]
[[Category: Roos AK]]
[[Category: Ugochukwu E]]
[[Category: W Yue W]]
[[Category: Weigelt J]]
[[Category: Von Delft F]]