View source for 2vsv


==Crystal structure of the PDZ domain of human rhophilin-2==
<StructureSection load='2vsv' size='340' side='right'caption='[[2vsv]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2vsv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VSV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vsv OCA], [https://pdbe.org/2vsv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vsv RCSB], [https://www.ebi.ac.uk/pdbsum/2vsv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vsv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RHPN2_HUMAN RHPN2_HUMAN] Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity.<ref>PMID:12221077</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vs/2vsv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vsv ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Burgess-Brown N]]
[[Category: Edwards A]]
[[Category: Elkins J]]
[[Category: Kochan G]]
[[Category: Murray JW]]
[[Category: Oppermann U]]
[[Category: Pike ACW]]
[[Category: Pilka ES]]
[[Category: Roos A]]
[[Category: Shafqat N]]
[[Category: Sun Z]]
[[Category: Wikstrom M]]
[[Category: Von Delft F]]