View source for 2vsp


==Crystal structure of the fourth PDZ domain of PDZ domain-containing protein 1==
<StructureSection load='2vsp' size='340' side='right'caption='[[2vsp]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2vsp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VSP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VSP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.41&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vsp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vsp OCA], [https://pdbe.org/2vsp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vsp RCSB], [https://www.ebi.ac.uk/pdbsum/2vsp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vsp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NHRF3_HUMAN NHRF3_HUMAN] A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vs/2vsp_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vsp ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Sodium-hydrogen exchange regulatory factor 3D structures|Sodium-hydrogen exchange regulatory factor 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith C]]
[[Category: Bountra C]]
[[Category: Cooper C]]
[[Category: Doyle D]]
[[Category: Edwards A]]
[[Category: Elkins J]]
[[Category: Johansson C]]
[[Category: Murray JW]]
[[Category: Oppermann U]]
[[Category: Phillips C]]
[[Category: Pilka ES]]
[[Category: Roos A]]
[[Category: Salah E]]
[[Category: Shafqat N]]
[[Category: Wikstrom M]]
[[Category: Yue WW]]
[[Category: Von Delft F]]