View source for 2r37


==Crystal structure of human glutathione peroxidase 3 (selenocysteine to glycine mutant)==
<StructureSection load='2r37' size='340' side='right'caption='[[2r37]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2r37]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R37 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R37 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r37 OCA], [https://pdbe.org/2r37 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r37 RCSB], [https://www.ebi.ac.uk/pdbsum/2r37 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r37 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GPX3_HUMAN GPX3_HUMAN] Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r3/2r37_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r37 ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Glutathione peroxidase|Glutathione peroxidase]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Edwards AM]]
[[Category: Gileadi O]]
[[Category: Guo K]]
[[Category: Johannson C]]
[[Category: Kavanagh KL]]
[[Category: Oppermann U]]
[[Category: Pike ACW]]
[[Category: Pilka ES]]
[[Category: Rojkowa A]]
[[Category: Sundstrom M]]
[[Category: Weigelt J]]
[[Category: Von Delft F]]