View source for 2n1q


==HIV-1 Core Packaging Signal==
<StructureSection load='2n1q' size='340' side='right'caption='[[2n1q]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2n1q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N1Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N1Q FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n1q OCA], [https://pdbe.org/2n1q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n1q RCSB], [https://www.ebi.ac.uk/pdbsum/2n1q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n1q ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
The 5' leader of the HIV-1 genome contains conserved elements that direct selective packaging of the unspliced, dimeric viral RNA into assembling particles. By using a (2)H-edited nuclear magnetic resonance (NMR) approach, we determined the structure of a 155-nucleotide region of the leader that is independently capable of directing packaging (core encapsidation signal; Psi(CES)). The RNA adopts an unexpected tandem three-way junction structure, in which residues of the major splice donor and translation initiation sites are sequestered by long-range base pairing and guanosines essential for both packaging and high-affinity binding to the cognate Gag protein are exposed in helical junctions. The structure reveals how translation is attenuated, Gag binding promoted, and unspliced dimeric genomes selected, by the RNA conformer that directs packaging.

RNA structure. Structure of the HIV-1 RNA packaging signal.,Keane SC, Heng X, Lu K, Kharytonchyk S, Ramakrishnan V, Carter G, Barton S, Hosic A, Florwick A, Santos J, Bolden NC, McCowin S, Case DA, Johnson BA, Salemi M, Telesnitsky A, Summers MF Science. 2015 May 22;348(6237):917-21. doi: 10.1126/science.aaa9266. PMID:25999508<ref>PMID:25999508</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
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</StructureSection>
[[Category: Human immunodeficiency virus 1]]
[[Category: Large Structures]]
[[Category: Keane SC]]
[[Category: Summers MF]]