View source for 2mlr


==Membrane Bilayer complex with Matrix Metalloproteinase-12 at its Alpha-face==
<StructureSection load='2mlr' size='340' side='right'caption='[[2mlr]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2mlr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MLR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MLR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PX4:1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PX4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mlr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mlr OCA], [https://pdbe.org/2mlr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mlr RCSB], [https://www.ebi.ac.uk/pdbsum/2mlr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mlr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.

==See Also==
*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Fulcher YG]]
[[Category: Koppisetti RK]]
[[Category: Lenoir M]]
[[Category: Overduin M]]
[[Category: Prior SH]]
[[Category: Van Doren SR]]