View source for 2lla


==NMR solution structure ensemble of domain 11 of the echidna M6P/IGF2R receptor==
<StructureSection load='2lla' size='340' side='right'caption='[[2lla]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2lla]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tachyglossus_aculeatus Tachyglossus aculeatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LLA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LLA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lla OCA], [https://pdbe.org/2lla PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lla RCSB], [https://www.ebi.ac.uk/pdbsum/2lla PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lla ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q95LC7_TACAU Q95LC7_TACAU] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Placental development and genomic imprinting coevolved with parental conflict over resource distribution to mammalian offspring. The imprinted genes IGF2 and IGF2R code for the growth promoter insulin-like growth factor 2 (IGF2) and its inhibitor, mannose 6-phosphate (M6P)/IGF2 receptor (IGF2R), respectively. M6P/IGF2R of birds and fish do not recognize IGF2. In monotremes, which lack imprinting, IGF2 specifically bound M6P/IGF2R via a hydrophobic CD loop. We show that the DNA coding the CD loop in monotremes functions as an exon splice enhancer (ESE) and that structural evolution of binding site loops (AB, HI, FG) improved therian IGF2 affinity. We propose that ESE evolution led to the fortuitous acquisition of IGF2 binding by M6P/IGF2R that drew IGF2R into parental conflict; subsequent imprinting may then have accelerated affinity maturation.

An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.,Williams C, Hoppe HJ, Rezgui D, Strickland M, Forbes BE, Grutzner F, Frago S, Ellis RZ, Wattana-Amorn P, Prince SN, Zaccheo OJ, Nolan CM, Mungall AJ, Jones EY, Crump MP, Hassan AB Science. 2012 Nov 30;338(6111):1209-13. doi: 10.1126/science.1228633. PMID:23197533<ref>PMID:23197533</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2lla" style="background-color:#fffaf0;"></div>

==See Also==
*[[Insulin-like growth factor receptor|Insulin-like growth factor receptor]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Tachyglossus aculeatus]]
[[Category: Crump MP]]
[[Category: Ellis RZ]]
[[Category: Forbes BE]]
[[Category: Frago S]]
[[Category: Hassan AZ]]
[[Category: Hoppe H]]
[[Category: Jones E]]
[[Category: Prince SN]]
[[Category: Rezgui D]]
[[Category: Strickland M]]
[[Category: Wattana-Amorn P]]
[[Category: Williams C]]
[[Category: Zaccheo OJ]]