View source for 2jvg


==Structure of C3-binding domain 4 of Staphylococcus aureus protein Sbi==
<StructureSection load='2jvg' size='340' side='right'caption='[[2jvg]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2jvg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JVG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jvg OCA], [https://pdbe.org/2jvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jvg RCSB], [https://www.ebi.ac.uk/pdbsum/2jvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jvg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SBI_STAAM SBI_STAAM] Plays a role in the inhibition of both the innate and adaptive immune responses. Possesses two N-terminal domains that bind the Fc region of IgG and two domains that form a tripartite complex with complement factors C3b and CFH. By recruiting CFH and C3b, the secreted form acts as a potent complement inhibitor of the alternative pathway-mediated lysis.[UniProtKB:A6QJQ7]<ref>PMID:18550524</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Bagby S]]
[[Category: Burman J]]
[[Category: Clark EA]]
[[Category: Upadhyay A]]
[[Category: Van den Elsen JMH]]