View source for 2fm2


==HCV NS3-4A protease domain complexed with a ketoamide inhibitor, SCH446211==
<StructureSection load='2fm2' size='340' side='right'caption='[[2fm2]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2fm2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_C Hepacivirus C] and [https://en.wikipedia.org/wiki/Hepatitis_C_virus_genotype_1a Hepatitis C virus genotype 1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FM2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FM2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3BC:TERT-BUTYL+[(1S)-1-({(1R,2S,5S)-2-[(3S,10S)-3-(CYCLOPROPYLMETHYL)-12-METHYL-4,5,8,11-TETRAOXO-10-PHENYL-2,6,9,12-TETRAAZATRIDECAN-1+-OYL]-6,6-DIMETHYL-3-AZABICYCLO[3.1.0]HEX-3-YL}CARBONYL)-2,2-DIMETHYLPROPYL]CARBAMATE'>3BC</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fm2 OCA], [https://pdbe.org/2fm2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fm2 RCSB], [https://www.ebi.ac.uk/pdbsum/2fm2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fm2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9ELS8_9HEPC Q9ELS8_9HEPC] 

==See Also==
*[[Helicase 3D structures|Helicase 3D structures]]
*[[Virus protease 3D structures|Virus protease 3D structures]]
__TOC__
</StructureSection>
[[Category: Hepacivirus C]]
[[Category: Hepatitis C virus genotype 1a]]
[[Category: Large Structures]]
[[Category: Bogen SL]]
[[Category: Bourne N]]
[[Category: Chase R]]
[[Category: Chen T]]
[[Category: Lemon SM]]
[[Category: Malcolm BA]]
[[Category: Njoroge FG]]
[[Category: Prongay A]]
[[Category: Pyles RB]]
[[Category: Saksena AK]]
[[Category: Skelton A]]
[[Category: Tong X]]
[[Category: Veselenak RL]]
[[Category: Yi M]]