View source for 2fe5


==The Crystal Structure of the Second PDZ Domain of Human DLG3==
<StructureSection load='2fe5' size='340' side='right'caption='[[2fe5]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2fe5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FE5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FE5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fe5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fe5 OCA], [https://pdbe.org/2fe5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fe5 RCSB], [https://www.ebi.ac.uk/pdbsum/2fe5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fe5 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/DLG3_HUMAN DLG3_HUMAN] Defects in DLG3 are the cause of mental retardation X-linked type 90 (MRX90) [MIM:[https://omim.org/entry/300850 300850]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.<ref>PMID:15185169</ref> 
== Function ==
[https://www.uniprot.org/uniprot/DLG3_HUMAN DLG3_HUMAN] Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fe/2fe5_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fe5 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith C]]
[[Category: Berridge G]]
[[Category: Bray J]]
[[Category: Bunkoczi G]]
[[Category: Colebrook S]]
[[Category: Debreczeni J]]
[[Category: Doyle D]]
[[Category: Edwards A]]
[[Category: Elkins J]]
[[Category: Gorrec F]]
[[Category: Phillips C]]
[[Category: Salah E]]
[[Category: Savitsky P]]
[[Category: Schoch G]]
[[Category: Smee C]]
[[Category: Sundstrom M]]
[[Category: Turnbull A]]
[[Category: Ugochukwu E]]
[[Category: Weigelt J]]
[[Category: Von Delft F]]