View source for 2enm


==Solution structure of the SH3 domain from mouse sorting nexin-9==
<StructureSection load='2enm' size='340' side='right'caption='[[2enm]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2enm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ENM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ENM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2enm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2enm OCA], [https://pdbe.org/2enm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2enm RCSB], [https://www.ebi.ac.uk/pdbsum/2enm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2enm ProSAT], [https://www.topsan.org/Proteins/RSGI/2enm TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SNX9_MOUSE SNX9_MOUSE] May be involved in several stages of intracellular trafficking. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/en/2enm_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2enm ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Sorting nexin 3D structures|Sorting nexin 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Hayashi F]]
[[Category: Kurosaki C]]
[[Category: Wakabayashi M]]
[[Category: Yokoyama S]]
[[Category: Yoshida M]]