View source for 2emb


==Solution structure of the C2H2 type zinc finger (region 342-372) of human Zinc finger protein 473==
<StructureSection load='2emb' size='340' side='right'caption='[[2emb]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2emb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EMB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EMB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2emb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2emb OCA], [https://pdbe.org/2emb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2emb RCSB], [https://www.ebi.ac.uk/pdbsum/2emb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2emb ProSAT], [https://www.topsan.org/Proteins/RSGI/2emb TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ZN473_HUMAN ZN473_HUMAN] Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases.<ref>PMID:11782445</ref> <ref>PMID:16914750</ref> <ref>PMID:16714279</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Abe H]]
[[Category: Kigawa T]]
[[Category: Kobayashi N]]
[[Category: Koshiba S]]
[[Category: Li H]]
[[Category: Saito K]]
[[Category: Sato M]]
[[Category: Tochio N]]
[[Category: Tomizawa T]]
[[Category: Yokoyama S]]