View source for 1ujv


==Solution structure of the second PDZ domain of human membrane associated guanylate kinase inverted-2 (MAGI-2)==
<StructureSection load='1ujv' size='340' side='right'caption='[[1ujv]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1ujv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UJV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ujv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ujv OCA], [https://pdbe.org/1ujv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ujv RCSB], [https://www.ebi.ac.uk/pdbsum/1ujv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ujv ProSAT], [https://www.topsan.org/Proteins/RSGI/1ujv TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MAGI2_HUMAN MAGI2_HUMAN] Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation.<ref>PMID:10760291</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uj/1ujv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ujv ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Guanylate kinase 3D structures|Guanylate kinase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Kigawa T]]
[[Category: Koshiba S]]
[[Category: Nameki N]]
[[Category: Yokoyama S]]