View source for 1mwh


==REOVIRUS POLYMERASE LAMBDA3 BOUND TO MRNA CAP ANALOG==
<StructureSection load='1mwh' size='340' side='right'caption='[[1mwh]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1mwh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Reovirus_sp. Reovirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MWH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MWH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTG:7-METHYL-GUANOSINE-5-TRIPHOSPHATE-5-GUANOSINE'>GTG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mwh OCA], [https://pdbe.org/1mwh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mwh RCSB], [https://www.ebi.ac.uk/pdbsum/1mwh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mwh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RDRP_REOVD RDRP_REOVD] RNA-directed RNA polymerase that is involved in transcription and genome replication. Following infection, it catalyzes the synthesis of fully conservative plus strands. After core assembly, which consists in recruitment of one capped plus-strand for each genomic segments and polymerase complexes, the polymerase switches mode and catalyzes the synthesis of complementary minus-strands.

==See Also==
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Reovirus sp]]
[[Category: Farsetta DL]]
[[Category: Harrison SC]]
[[Category: Nibert ML]]
[[Category: Tao Y]]