View source for 1gxg


==Non-cognate protein-protein interactions: the NMR structure of the colicin E8 inhibitor protein Im8 and its interaction with the DNase domain of colicin E9==
<StructureSection load='1gxg' size='340' side='right'caption='[[1gxg]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1gxg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1imz 1imz]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GXG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GXG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gxg OCA], [https://pdbe.org/1gxg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gxg RCSB], [https://www.ebi.ac.uk/pdbsum/1gxg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gxg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IMM8_ECOLX IMM8_ECOLX] This protein is able to protect a cell, which harbors the plasmid ColE8 encoding colicin E8, against colicin E8, it binds specifically to the DNase-type colicin and inhibits its bactericidal activity.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gx/1gxg_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gxg ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Colicin immunity protein 3D structures|Colicin immunity protein 3D structures]]
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Boetzel R]]
[[Category: Czisch M]]
[[Category: James R]]
[[Category: Kleanthous C]]
[[Category: Le Duff CS]]
[[Category: Moore GR]]
[[Category: Videler H]]