Tryptase inhibitor

Tryptase inhibitors (TI) are protein inhibitors of tryptase belonging to the group of Kazal-type inhibitors and exhibiting a distinctive disulfide pattern^[1].

Relevance

TI are used as anti-inflammatory agents in treating asthma and other airway inflammation diseases. Tryptase was found in elevated levels in various kinds of allergic inflammations.

(PDB entry 1ldt).

Structure of leech tryptase inhibitor (magenta) complex with trypsin (cyan) and Ca+2 ion (green) (PDB entry 1ldt)

Drag the structure with the mouse to rotate

3D structures of tryptase inhibitor3D structures of tryptase inhibitor

Updated on 03-October-2019

ReferencesReferences

↑ Stubbs MT, Morenweiser R, Sturzebecher J, Bauer M, Bode W, Huber R, Piechottka GP, Matschiner G, Sommerhoff CP, Fritz H, Auerswald EA. The three-dimensional structure of recombinant leech-derived tryptase inhibitor in complex with trypsin. Implications for the structure of human mast cell tryptase and its inhibition. J Biol Chem. 1997 Aug 8;272(32):19931-7. PMID:9242660

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Michal Harel, Alexander Berchansky

[1] Stubbs MT, Morenweiser R, Sturzebecher J, Bauer M, Bode W, Huber R, Piechottka GP, Matschiner G, Sommerhoff CP, Fritz H, Auerswald EA. The three-dimensional structure of recombinant leech-derived tryptase inhibitor in complex with trypsin. Implications for the structure of human mast cell tryptase and its inhibition. J Biol Chem. 1997 Aug 8;272(32):19931-7. PMID:9242660

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