Shikimate kinase

Function

Shikimate kinase (SK) catalyzes the ATP-dependent phosphorylation of shikimate to produce shikimate 3-phosphate. It is part of the plant and bacteria pathway of synthesizing aromatic acids^[1].

Relevance

SK inhibitors can be used as antimicrobial drugs^[2].

Structural highlights

The active site of SK contains the substrate shikimate and an ADP molecule^[3].

. Water molecules are shown as red spheres.
.

3D Structures of shikimate kinase

Shikimate kinase 3D structures

References

↑ Saidemberg DM, Passarelli AW, Rodrigues AV, Basso LA, Santos DS, Palma MS. Shikimate kinase (EC 2.7.1.71) from Mycobacterium tuberculosis: kinetics and structural dynamics of a potential molecular target for drug development. Curr Med Chem. 2011;18(9):1299-310. PMID:21366533
↑ Gordon S, Simithy J, Goodwin DC, Calderon AI. Selective Mycobacterium tuberculosis Shikimate Kinase Inhibitors as Potential Antibacterials. Perspect Medicin Chem. 2015 Mar 15;7:9-20. doi: 10.4137/PMC.S13212. eCollection, 2015. PMID:25861218 doi:http://dx.doi.org/10.4137/PMC.S13212
↑ Dias MV, Faim LM, Vasconcelos IB, de Oliveira JS, Basso LA, Santos DS, de Azevedo WF Jr. Effects of the magnesium and chloride ions and shikimate on the structure of shikimate kinase from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jan 1;63(Pt 1):1-6., Epub 2006 Dec 16. PMID:17183161 doi:10.1107/S1744309106046823

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Michal Harel, Alexander Berchansky

[1] Saidemberg DM, Passarelli AW, Rodrigues AV, Basso LA, Santos DS, Palma MS. Shikimate kinase (EC 2.7.1.71) from Mycobacterium tuberculosis: kinetics and structural dynamics of a potential molecular target for drug development. Curr Med Chem. 2011;18(9):1299-310. PMID:21366533

[2] Gordon S, Simithy J, Goodwin DC, Calderon AI. Selective Mycobacterium tuberculosis Shikimate Kinase Inhibitors as Potential Antibacterials. Perspect Medicin Chem. 2015 Mar 15;7:9-20. doi: 10.4137/PMC.S13212. eCollection, 2015. PMID:25861218 doi:http://dx.doi.org/10.4137/PMC.S13212

[3] Dias MV, Faim LM, Vasconcelos IB, de Oliveira JS, Basso LA, Santos DS, de Azevedo WF Jr. Effects of the magnesium and chloride ions and shikimate on the structure of shikimate kinase from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jan 1;63(Pt 1):1-6., Epub 2006 Dec 16. PMID:17183161 doi:10.1107/S1744309106046823

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