Shikimate dehydrogenase

Function Shikimate dehydrogenase (AroE) catalyzes the conversion of shikimate and NADP+ to 3-dihydroshikimate, NADPH and H+. It is part of the shikimate pathway which is responsible for the biosynthesis of phenylalanine, tyrosine and tryptophan. This pathway is found in bacteria, fungi, plants, algae and parasites and is missing in animals and humans. Structural highlights AroE changes its conformation from an open to closed one upon binding of the cofactor NADP. The active site contains the substrate shikimate. . Water molecules are shown as red spheres. . 3D Structures of shikimate dehydrogenase Shikimate dehydrogenase 3D structures

spinqualitylabelsall models Shikimate dehydrogenase dimer complex with shikimate, sulfate and NADP 2ev9 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image