Sandbox29

1EVE1EVE

This sandbox is in use until June 1, 2009 for UMass Chemistry 490a. Others please do not edit this page. Thanks!

Created by Lori Mathis

1eve is a protein that is a drug used to prevent Alzheimer disease. The of 1EVE contains 2 types of amphipathic elements; 15 and 16 . 1eve is a fairly standard molecule in the sense that the aspects of the protein are well-maintained on the inside, while the hydrophillic portions are around the outside. 1eve has an active name called Acetylcholinesterase, which has a ligand called Aricept. There is an in the middle of the molecule. 1eve is considered an AChE inhibitor, in which it has a high affinity for. The overall protein itself was created by a Japanese corporation called the Eisai Company.

1eve, resolution 2.50Å ()

Ligands:

,

Activity:

Acetylcholinesterase, with EC number 3.1.1.7

Structural annotation:
Resources:	CATH : 1Eve000 InterPro : Ipr000908, Ipr002018, Ipr000997 Pfam : PF00135 SCOP : d1eve__ UniProt : P04058

Functional annotation:
Cellular component:	synapse cell junction membrane
Biological process:	neurotransmitter catabolic process acetylcholine catabolic process in synaptic cleft
Molecular function:	cholinesterase activity hydrolase activity GPI anchor binding acetylcholinesterase activity

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

Reference to the Proteopedia pages dedicated to 1EVE, contributors are Eran Hodis, Joel L. Sussman, OCA, Wayne Decatur

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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