Ribosomal protein S19

Function

Ribosomal protein S19 (RPS19) is one of the 21 proteins which belong to the 30S of the bacterial ribosome or the 30 proteins which belong to the 40S small subunit of the eukaryotic ribosome. It forms a complex with RPS13 that binds to 16S RRNA^[1].

Relevance

RPS19 is a potent anti-inflammatory agent which appears to work primarily by inhibiting MIF signaling^[2].

3D Structures of Ribosomal protein S193D Structures of Ribosomal protein S19

Updated on 01-October-2017

2v7f – RPS19 – Pyroccocus abyssi
1qkh, 1qkf - TtRPS19 - Thermus thermophilus – NMR
3a1p – TtRPS19 + ribosome maturation factor

ReferencesReferences

↑ Wool IG, Chan YL, Gluck A. Structure and evolution of mammalian ribosomal proteins. Biochem Cell Biol. 1995 Nov-Dec;73(11-12):933-47. PMID:8722009
↑ Lv J, Huang XR, Klug J, Frohlich S, Lacher P, Xu A, Meinhardt A, Lan HY. Ribosomal protein S19 is a novel therapeutic agent in inflammatory kidney disease. Clin Sci (Lond). 2013 May;124(10):627-37. doi: 10.1042/CS20120526. PMID:23252627 doi:http://dx.doi.org/10.1042/CS20120526

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Alexander Berchansky, Michal Harel, Joel L. Sussman

[1] Wool IG, Chan YL, Gluck A. Structure and evolution of mammalian ribosomal proteins. Biochem Cell Biol. 1995 Nov-Dec;73(11-12):933-47. PMID:8722009

[2] Lv J, Huang XR, Klug J, Frohlich S, Lacher P, Xu A, Meinhardt A, Lan HY. Ribosomal protein S19 is a novel therapeutic agent in inflammatory kidney disease. Clin Sci (Lond). 2013 May;124(10):627-37. doi: 10.1042/CS20120526. PMID:23252627 doi:http://dx.doi.org/10.1042/CS20120526

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