Ribosomal protein L2

Ribosomal protein L2 (RPL2) is one of the 34 proteins which belong to the of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It is required for the association of the 30S and 50S subunits and is involved in the binding of tRNA at the A- and P-sites^[1]. In the archaea like in Haloarcula marismortui, the L2 is called L2P (RPL2P). The structure of the RNA-binding domain of L2 from Bacillus stearothermophilus is shown on the right^[2].

3D Structures of Ribosomal protein L23D Structures of Ribosomal protein L2

Updated on 27-February-2022

- 1rl2 – RPL2 (mutant) – Geobacillus stearothermophilus
Ribosomal protein L2 in part of the large ribosomal subunit
- 487d – RPL2+RPL1+RPL6+RPL9+RPL11+RPL14+RPL25 - Thermus thermophilus - Cryo-EM
- 1c04 – HmRPL2P+RPL6+RPL11+RPS14+23S RRNA fragment - Haloarcula marismortui

ReferencesReferences

↑ Rippa V, Cirulli C, Di Palo B, Doti N, Amoresano A, Duilio A. The ribosomal protein L2 interacts with the RNA polymerase alpha subunit and acts as a transcription modulator in Escherichia coli. J Bacteriol. 2010 Apr;192(7):1882-9. doi: 10.1128/JB.01503-09. Epub 2010 Jan 22. PMID:20097853 doi:http://dx.doi.org/10.1128/JB.01503-09
↑ Nakagawa A, Nakashima T, Taniguchi M, Hosaka H, Kimura M, Tanaka I. The three-dimensional structure of the RNA-binding domain of ribosomal protein L2; a protein at the peptidyl transferase center of the ribosome. EMBO J. 1999 Mar 15;18(6):1459-67. PMID:10075918 doi:10.1093/emboj/18.6.1459

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[1] Rippa V, Cirulli C, Di Palo B, Doti N, Amoresano A, Duilio A. The ribosomal protein L2 interacts with the RNA polymerase alpha subunit and acts as a transcription modulator in Escherichia coli. J Bacteriol. 2010 Apr;192(7):1882-9. doi: 10.1128/JB.01503-09. Epub 2010 Jan 22. PMID:20097853 doi:http://dx.doi.org/10.1128/JB.01503-09

[2] Nakagawa A, Nakashima T, Taniguchi M, Hosaka H, Kimura M, Tanaka I. The three-dimensional structure of the RNA-binding domain of ribosomal protein L2; a protein at the peptidyl transferase center of the ribosome. EMBO J. 1999 Mar 15;18(6):1459-67. PMID:10075918 doi:10.1093/emboj/18.6.1459

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