Ribokinase

Function

Ribokinase (RK) catalyzes the first step of ribose metabolism by phosphorylating it at the O5' position ^[1]. ATP serves as the co-substrate of RK.

Structural highlights

Upon forming a ternary complex of RK, ribose and nucleotide the RK dimer changes its open form to a closed one. The ribose substrate is seen between a small β-sheel domain and the concave side of the central β sheet^[2]. is lined with charged residues. Water molecules are shown as red spheres. The is surrounded by hydrophobic residues. .

Ribokinase 3D structures

Ribokinase dimer complexed with ribose, ATP and Na+ ion (PDB id 6ils)

Drag the structure with the mouse to rotate

ReferencesReferences

↑ Sigrell JA, Cameron AD, Mowbray SL. Induced fit on sugar binding activates ribokinase. J Mol Biol. 1999 Jul 30;290(5):1009-18. PMID:10438599 doi:10.1006/jmbi.1999.2938
↑ Kang PA, Oh J, Lee H, Witte CP, Rhee S. Crystal structure and mutational analyses of ribokinase from Arabidopsis thaliana. J Struct Biol. 2019 Feb 26. pii: S1047-8477(19)30030-9. doi:, 10.1016/j.jsb.2019.02.007. PMID:30822455 doi:http://dx.doi.org/10.1016/j.jsb.2019.02.007

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Michal Harel, Alexander Berchansky

[1] Sigrell JA, Cameron AD, Mowbray SL. Induced fit on sugar binding activates ribokinase. J Mol Biol. 1999 Jul 30;290(5):1009-18. PMID:10438599 doi:10.1006/jmbi.1999.2938

[2] Kang PA, Oh J, Lee H, Witte CP, Rhee S. Crystal structure and mutational analyses of ribokinase from Arabidopsis thaliana. J Struct Biol. 2019 Feb 26. pii: S1047-8477(19)30030-9. doi:, 10.1016/j.jsb.2019.02.007. PMID:30822455 doi:http://dx.doi.org/10.1016/j.jsb.2019.02.007

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