Ras GTPase activating protein

Function

Ras GTPase activating protein (RasGAP) inactivates Ras from its active GTP-bound form to its GDP-bound form^[1]. It is part of the mitogenic signal transmission via its N-terminal SH2-SH3-SH2 domains.

SynGAP is a neuronal RasGAP expressed in brain and negatively regulates Ras activity and its signaling pathways^[2].

Relevance

Inactivated RasGAP activate RAS which is mutated in 30% of cancer types^[3]. RasGAP Colra1 is involved in infection-related morphogenesis in gourd family plants^[4].

Human Ras GTPase activating protein dimer SH3 domain (PDB code 2j05).

Drag the structure with the mouse to rotate

3D Structures of Ras GTPase activating protein3D Structures of Ras GTPase activating protein

Updated on 04-August-2024

ReferencesReferences

↑ Tocque B, Delumeau I, Parker F, Maurier F, Multon MC, Schweighoffer F. Ras-GTPase activating protein (GAP): a putative effector for Ras. Cell Signal. 1997 Feb;9(2):153-8. PMID:9113414
↑ Kim JH, Lee HK, Takamiya K, Huganir RL. The role of synaptic GTPase-activating protein in neuronal development and synaptic plasticity. J Neurosci. 2003 Feb 15;23(4):1119-24. PMID:12598599 doi:10.1523/JNEUROSCI.23-04-01119.2003
↑ Maertens O, Cichowski K. An expanding role for RAS GTPase activating proteins (RAS GAPs) in cancer. Adv Biol Regul. 2014 May;55:1-14. doi: 10.1016/j.jbior.2014.04.002. Epub 2014 Apr, 30. PMID:24814062 doi:http://dx.doi.org/10.1016/j.jbior.2014.04.002
↑ Harata K, Kubo Y. Ras GTPase activating protein CoIra1 is involved in infection-related morphogenesis by regulating cAMP and MAPK signaling pathways through CoRas2 in Colletotrichum orbiculare. PLoS One. 2014 Oct 2;9(9):e109045. doi: 10.1371/journal.pone.0109045. eCollection, 2014. PMID:25275394 doi:http://dx.doi.org/10.1371/journal.pone.0109045

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

[1] Tocque B, Delumeau I, Parker F, Maurier F, Multon MC, Schweighoffer F. Ras-GTPase activating protein (GAP): a putative effector for Ras. Cell Signal. 1997 Feb;9(2):153-8. PMID:9113414

[2] Kim JH, Lee HK, Takamiya K, Huganir RL. The role of synaptic GTPase-activating protein in neuronal development and synaptic plasticity. J Neurosci. 2003 Feb 15;23(4):1119-24. PMID:12598599 doi:10.1523/JNEUROSCI.23-04-01119.2003

[3] Maertens O, Cichowski K. An expanding role for RAS GTPase activating proteins (RAS GAPs) in cancer. Adv Biol Regul. 2014 May;55:1-14. doi: 10.1016/j.jbior.2014.04.002. Epub 2014 Apr, 30. PMID:24814062 doi:http://dx.doi.org/10.1016/j.jbior.2014.04.002

[4] Harata K, Kubo Y. Ras GTPase activating protein CoIra1 is involved in infection-related morphogenesis by regulating cAMP and MAPK signaling pathways through CoRas2 in Colletotrichum orbiculare. PLoS One. 2014 Oct 2;9(9):e109045. doi: 10.1371/journal.pone.0109045. eCollection, 2014. PMID:25275394 doi:http://dx.doi.org/10.1371/journal.pone.0109045

[1]

[2]

[3]

[4]