Raptor

Raptor (Rap) or Regulatory-Associated Protein of TOR 1 binds mTOR which controls cell growth, p70 S6 kinase α (S6K1) and the the initiation factor 4E binding protein 1 (4EBP1). The binding of Rap to mTOR is necessary for the mTOR-catayzed phosphorylation of the initiation factor binding protein ^[1].

3D structures of raptor

Raptor 3D structures

References

↑ Chong ZZ, Shang YC, Maiese K. Cardiovascular disease and mTOR signaling. Trends Cardiovasc Med. 2011 Jul;21(5):151-5. doi: 10.1016/j.tcm.2012.04.005. PMID:22732551 doi:http://dx.doi.org/10.1016/j.tcm.2012.04.005

Raptor (grey) in complex with human 4EBP1 peptide (mustard) PDB code 5wbj

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

[1] Chong ZZ, Shang YC, Maiese K. Cardiovascular disease and mTOR signaling. Trends Cardiovasc Med. 2011 Jul;21(5):151-5. doi: 10.1016/j.tcm.2012.04.005. PMID:22732551 doi:http://dx.doi.org/10.1016/j.tcm.2012.04.005

[1]