Rapamycin

Rapamycin, isolated from the bacterium Streptomyces hygroscopicus, is an immuno-suppressant and anticancer drug^[1]. It acts by binding the the mTORC1 protein complex, a kinase that regulates cell growth and metabolism. In the future, it might also be used in treatment of type 2 diabetes^[2].

StructureStructure

Rapamycin, a macrolide, has a . It with the help of another protein called FKBP52^[3]

ReferencesReferences

↑ https://en.wikipedia.org/wiki/Sirolimus
↑ https://doi.org/10.3389/fphar.2016.00395
↑ Marz AM, Fabian AK, Kozany C, Bracher A, Hausch F. Large FK506-binding Proteins Shape the Pharmacology of Rapamycin. Mol Cell Biol. 2013 Jan 28. PMID:23358420 doi:http://dx.doi.org/10.1128/MCB.00678-12

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Karsten Theis

[1] ttps://en.wikipedia.org/wiki/Sirolimus

[2] ttps://doi.org/10.3389/fphar.2016.00395

[3] Marz AM, Fabian AK, Kozany C, Bracher A, Hausch F. Large FK506-binding Proteins Shape the Pharmacology of Rapamycin. Mol Cell Biol. 2013 Jan 28. PMID:23358420 doi:http://dx.doi.org/10.1128/MCB.00678-12

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