Proteopedia

Rac GTPase-activating protein


Function

Rac GTPase-activating protein 1 (RacGAP1) is required for the attachment of the midbody to the cell membrane during cytokinesis. It is involved in the regulation of growth-related processes in adipocytes and myoblasts.

Relevance

RacGAP1 expression is a prognostic marker for HBV-positive human hepatocellular carcinoma and can be a potential molecular target for therapeutic strategies against this carcinoma[1].


Human Rac GTPase-activating protein 1 GAP domain (grey) complex with CDC42 (green) and GDP (PDB code 5c2j)

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3D structures of Rac GTPase-activating protein 13D structures of Rac GTPase-activating protein 1

Updated on 23-October-2017

3w6r, 2ovj – hRacGAP GAP domain – human
3wpq, 3wps – hRacGAP GAP domain (mutant)
4b6d – hRacGAP C1 domain
5c2j – hRacGAP GAP domain + CDC42 + GDP

ReferencesReferences

  1. ↑ Wang SM, Ooi LL, Hui KM. Upregulation of Rac GTPase-activating protein 1 is significantly associated with the early recurrence of human hepatocellular carcinoma. Clin Cancer Res. 2011 Sep 15;17(18):6040-51. doi: 10.1158/1078-0432.CCR-11-0557. , Epub 2011 Aug 8. PMID:21825042 doi:http://dx.doi.org/10.1158/1078-0432.CCR-11-0557

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Michal Harel
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