Prestin

Function

Prestin (Pre) is a motor protein found in the outer hair cells of the cochlea. It is essential for mammalian hearing. Pre is a membranal anion transporter^[1]. See STAS domain of the SLC26 anion transporter prestin.

Disease

Mutations in Pre are associated with non-syndromic hearing loss^[2].

Structural highlights

Pre C-terminal is mainly composed of a STAS (Sulfate Transporters and Anti-Sigma factor antagonist) domain^[3].

. Water molecules are shown as red spheres.
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Rat prestin STAS domain complex with Cl- ion and ethylene glycol (PDB code 5euu)

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3D Structures of prestin3D Structures of prestin

Updated on 12-September-2023

7lgu, 7lgw, 7lh3, 7v73, 7v74 – hPre – human – Cryo EM
7lh2, 7v75 – hPre + salicylate – Cryo EM
3llo – rPre STAS domain – rat
5eus – rPre STAS domain + Br
5euu – rPre STAS domain + Cl
5euz – rPre STAS domain + I
5euw – rPre STAS domain + NO3
5eux – rPre STAS domain + CNS
7sun – Pre – gerbil – Cryo EM
5ezb – Pre STAS domain - chicken
7s8x, 7s9b, 7s9c, 7s9d – dPre – dolphin – Cryo EM
7s9a, 7s9e – dPre + salicylate – Cryo EM

ReferencesReferences

↑ Zheng J, Shen W, He DZ, Long KB, Madison LD, Dallos P. Prestin is the motor protein of cochlear outer hair cells. Nature. 2000 May 11;405(6783):149-55. PMID:10821263 doi:http://dx.doi.org/10.1038/35012009
↑ Liu XZ, Ouyang XM, Xia XJ, Zheng J, Pandya A, Li F, Du LL, Welch KO, Petit C, Smith RJ, Webb BT, Yan D, Arnos KS, Corey D, Dallos P, Nance WE, Chen ZY. Prestin, a cochlear motor protein, is defective in non-syndromic hearing loss. Hum Mol Genet. 2003 May 15;12(10):1155-62. PMID:12719379
↑ Pasqualetto E, Aiello R, Gesiot L, Bonetto G, Bellanda M, Battistutta R. Structure of the cytosolic portion of the motor protein prestin and functional role of the STAS domain in SLC26/SulP anion transporters. J Mol Biol. 2010 Jul 16;400(3):448-62. Epub 2010 May 21. PMID:20471983 doi:10.1016/j.jmb.2010.05.013

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Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Zheng J, Shen W, He DZ, Long KB, Madison LD, Dallos P. Prestin is the motor protein of cochlear outer hair cells. Nature. 2000 May 11;405(6783):149-55. PMID:10821263 doi:http://dx.doi.org/10.1038/35012009

[2] Liu XZ, Ouyang XM, Xia XJ, Zheng J, Pandya A, Li F, Du LL, Welch KO, Petit C, Smith RJ, Webb BT, Yan D, Arnos KS, Corey D, Dallos P, Nance WE, Chen ZY. Prestin, a cochlear motor protein, is defective in non-syndromic hearing loss. Hum Mol Genet. 2003 May 15;12(10):1155-62. PMID:12719379

[3] Pasqualetto E, Aiello R, Gesiot L, Bonetto G, Bellanda M, Battistutta R. Structure of the cytosolic portion of the motor protein prestin and functional role of the STAS domain in SLC26/SulP anion transporters. J Mol Biol. 2010 Jul 16;400(3):448-62. Epub 2010 May 21. PMID:20471983 doi:10.1016/j.jmb.2010.05.013

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