Pleurotolysin

Function

Pleurotolysin (PTL) is a pore-forming cytolysin from Pleurotus ostreatus. PTL is a two-component cytolysin composed of non-associated PTL A (17kDa) and PTL B (59kDa) which cooperatively cause leakage of potassium ions from human erythrocytes and swelling of the cells leading to colloid-osmotic hemolysis^[1]. (4v3a).

Pleurotoxin A (blue and green) complex with pleurotoxin B (pink) (PDB code 4v3a)

Drag the structure with the mouse to rotate

3D structures of pleurotolysin3D structures of pleurotolysin

Updated on 22-July-2024

- 4oeb – PoPTL – Pleurotus ostreatus
Pleurotolysin B

- 4oej – PoPTL
- 4ov8 – PoPTL (mutant)
Pleurotolysin A+B
- 4v2t, 4v3a, 4v3m, 4v3n – PoPTL - CryoEM

ReferencesReferences

↑ Tomita T, Noguchi K, Mimuro H, Ukaji F, Ito K, Sugawara-Tomita N, Hashimoto Y. Pleurotolysin, a novel sphingomyelin-specific two-component cytolysin from the edible mushroom Pleurotus ostreatus, assembles into a transmembrane pore complex. J Biol Chem. 2004 Jun 25;279(26):26975-82. Epub 2004 Apr 14. PMID:15084605 doi:http://dx.doi.org/10.1074/jbc.M402676200

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Tomita T, Noguchi K, Mimuro H, Ukaji F, Ito K, Sugawara-Tomita N, Hashimoto Y. Pleurotolysin, a novel sphingomyelin-specific two-component cytolysin from the edible mushroom Pleurotus ostreatus, assembles into a transmembrane pore complex. J Biol Chem. 2004 Jun 25;279(26):26975-82. Epub 2004 Apr 14. PMID:15084605 doi:http://dx.doi.org/10.1074/jbc.M402676200

[1]