Plasminogen activator

Function Plasminogen activator (PLA) is a serine protease which converts plasminogen to plasmin. TPA structure contains heavy and light chains (HC, LC). PLA is inhibited by PLA inhibitor 1 and 2. Tissue PLA (TPA) which is involved in breakdown of blood clots. Urokinase-type PLA see Urokinase. Coagulase/fibrinolysin is a plasminogen activator from Yersinia pestis which possesses coagulase activity is responsible for degradation of plasmid-coded outer membrane proteins. Relevance Treatment with tissue PLA for acute ischemic stroke is beneficial. Structural highlights . Water molecules are shown as red spheres. .

spinqualitylabelsall models Human tissue plasminogen activator light chain catalytic domain (sky blue and green), heavy chain catalytic domain fragment (yellow and pink) complex with benzamidine, 1a5h Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of plasminogen activator3D structures of plasminogen activator

Updated on 21-July-2024

{"openlevels":0}

• Plasminogen activator
  • 1a5i – PLA residues 213-477 + EGR-CMK – Vampire bat
    
  • 1bqy – PLA – Pit viper

• Tissue plasminogen activator; Domains – fibrin-binding 36-85; kringle 1 69-153; kringle 2 209-298; catalytic 311-561
  • 1a5h – hTPA HC+LC + benzamidine – human
    
  • 1rtf - hTPA HC+LC
    
  • 1tpg – hTPA F1-G - NMR
    
  • 1pk2 – hTPA kringle 2 domain + 6-aminohexanoic acid – NMR
    
  • 1tpk, 1pml - hTPA kringle 2 domain
    
  • 1kdu - hTPA kringle 1 domain – NMR
    
  • 1tpm, 1tpn - hTPA fibrin-binding domain – NMR
    
  • 1bda – hTPA catalytic domain (mutant) + EGR-CMK
    
  • 5brr, 5zlz - hTPA catalytic domain (mutant) + plasminogen activator inhibitor 1
    
• Coagulase/fibrinolysin
  • 2x55, 2x56 - YpTPA – Yersinia pestis
    
  • 2x4m - YpTPA (mutant)
    
  • 4dcb - YpTPA (mutant) + plasminogen peptide
    
• Urokinase-type plasminogen activator see Urokinase