Lignin peroxidase

Function

Lignin peroxidase or ligninase (Lip) catalyzes the biodegradation of lignin using hydrogen peroxide. Lignin comprises 20-30% of woody plants cell wall. It is made of branched and heterogenous structure of phenylpropanoid units. It is highly resistant to biodegradation and only higher fungi are capable of degrading it. Veratryl alcohol is the cofactor in this reaction^[1].

Relevance

Lip is used as a skin-lightening active agent^[2].

Structural highlights

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Lignin peroxidase containing heme complex with MPD, Ca+2 (large green), Na+ (purple) and Cl- (small green) ions (PDB entry 3q3u)

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3D structures of lignin peroxidase3D structures of lignin peroxidase

Updated on 17-October-2021

1lga, 1llp, 1qpa, 1b80, 1b82 – PcLip – Phanerochaete chrysosporium
1b85, 6a6q, 6iss – PcLip (mutant)
3q3u – Lip – Trametes cervina
7oo5 – Lip – Agrocybe pediades

ReferencesReferences

↑ Doyle WA, Blodig W, Veitch NC, Piontek K, Smith AT. Two substrate interaction sites in lignin peroxidase revealed by site-directed mutagenesis. Biochemistry. 1998 Oct 27;37(43):15097-105. PMID:9790672 doi:http://dx.doi.org/10.1021/bi981633h
↑ Zhong SM, Sun N, Liu HX, Niu YQ, Wu Y. Reduction of facial pigmentation of melasma by topical lignin peroxidase: A novel fast-acting skin-lightening agent. Exp Ther Med. 2015 Feb;9(2):341-344. Epub 2014 Dec 8. PMID:25574195 doi:http://dx.doi.org/10.3892/etm.2014.2118

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Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Doyle WA, Blodig W, Veitch NC, Piontek K, Smith AT. Two substrate interaction sites in lignin peroxidase revealed by site-directed mutagenesis. Biochemistry. 1998 Oct 27;37(43):15097-105. PMID:9790672 doi:http://dx.doi.org/10.1021/bi981633h

[2] Zhong SM, Sun N, Liu HX, Niu YQ, Wu Y. Reduction of facial pigmentation of melasma by topical lignin peroxidase: A novel fast-acting skin-lightening agent. Exp Ther Med. 2015 Feb;9(2):341-344. Epub 2014 Dec 8. PMID:25574195 doi:http://dx.doi.org/10.3892/etm.2014.2118

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