Alpha-lactalbumin

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Function

Alpha-lactalbumin (LCA) is the albumin contained in milk and obtained from whey[1]. LCA is the regulatory subunit of the lactose synthase heterodimer which produces lactose by transferring galactose moieties to glucose.

Relevance

LCA is tested as a target for potential breast cancer vaccine. LCA is the major whey protein of cow and sheep milk. LCA is the target of testing for the presence of milk as an allergen.

Structural highlights

  • . Water molecules shown as red spheres.
  • .

3D Structures of α-lactalbumin

Alpha-lactalbumin 3D structures


Human α-lactalbumin complex with sulfate, Zn+2 (grey) and Ca+2 (green) ions (PDB code 1hml).

Drag the structure with the mouse to rotate

ReferencesReferences

  1. Permyakov EA, Berliner LJ. alpha-Lactalbumin: structure and function. FEBS Lett. 2000 May 19;473(3):269-74. PMID:10818224

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Michal Harel, Jaime Prilusky, Alexander Berchansky