Increased sodium tolerance protein

Function Increased sodium tolerance protein 1 (Ist1) is a family member of the transport-III (ESCRT-III) forming high-order helical structures with CHMP1B which are required in remodeling membranes during abscission. Increased sodium tolerance protein 3 (Ist3) or U2 snRNP component IST3 (Ist3) is part of the spliceosome which is involved in transcription and pre-mRNA splicing. Ist3 interacts with human elongation factors and strongly stimulates polymerase elongation. Disease Somatic mutations in Ist3 have been found in various malignancies like breast cancer, pancreatic cancer, uveal melanoma and others. Structural highlights The structure of the yeast Ist1 N-terminal complex with ESCRT-III subunit Did2 which is part of a high-order helical structure shows pointing toward the Did2 helix. of Ist1 were found by mutational studies to interact with Did2. .

spinqualitylabelsall models Yeast Ist1 N-terminal (cyan) complex with ESCRT-III subunit Did2 (green) (PDB code 3ggz) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of increased sodium tolerance protein3D structures of increased sodium tolerance protein

Updated on 11-November-2020

{"openlevels":0}

• Increased sodium tolerance protein 1
  • 6tza - hIst1 N-terminal (mutant) 1-193 - human - Cryo EM
    
  • 3jc1, 6tz5, 6tz4 - hIst1 N-terminal + CHMP1B - Cryo EM
    
  • 6e8g - hIst1 N-terminal + CHMP1B + DNA - Cryo EM
    
  • 3ggy - yIst1 N-terminal - yeast
    
  • 3ggz - yIst1 N-terminal + vascular protei-sorting-associted protein 46 peptide
    
• Increased sodium tolerance protein 3 or U2 snRNP component IST3
  • 2my3 - yIst3 residues 25-138 + pre-mRNA leakage protein peptide - NMR
    
  • 2my2, 4uqt - yIst3 residues 25-138 + pre-mRNA-splicing factor peptide - NMR
    
  • 2my3 - yIst3 residues 25-138 + pre-mRNA leakage protein peptide + pre-mRNA-splicing factor peptide - NMR
    
  • 5lqw, 5zwo, 5zwm, 5gm6 - yIst3 in spliceosome - Cryo EM
    
  • 6g90, 5nrl - yIst3 in prespliceosome - Cryo EM