Guanylate kinase

Function Guanylate kinase (GK) catalyzes the transfer of phosphate from GMP to GDP using ATP as a phosphate source. GK is essential for recycling GMP and cGMP. GK also forms a domain in the membrane-associated GK (MAGUK) which functions in mitotic spindle orientation and cell adhesion. There is a single mutation in GK which converts it from an enzyme to a protein-binding GK domain. The GK domain has no catalytic activity. The MAGUK contain PDZ (protein-protein interaction domain), WW (proline-rich interaction domain), SH3 (domain found in signaling pathway proteins) and GK domains. Structural highlights The biological assembly of E. coli guanylate kinase is . The of GK is . 3D structures of guanylate kinase Guanylate kinase 3D structures

spinqualitylabelsall models E. coli guanylate kinase complex with GMP, sulfate (PDB entry 2anb) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image